دانلود مقاله انگلیسی با ترجمه بیماری پریودنتال، مکانیسم های التهابی آنالیز استخوان

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 ۲٫ Resident Cells and Innate Immunity

The resident cells involved in the innate host response are many including epithelial cells, gingival and periodontal ligament (PDL) fibroblasts, osteoblast, and dendritic cells [9]. Epithelial cells produce interleukin-8 (IL-8), a neutrophil chemoattractant, which recruits neutrophils migration [13] and increases monocyte adhesion in the blood vessels. Neutrophils that enter the periodontal environment are primed and exhibit increased production of proinflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-𝛼 (TNF-𝛼) [۱۴]. These cytokines mediate periodontal tissue destruction by stimulating bone resorption. Monocytes, on the other hand, can differentiate into osteoclasts (OCs) upon different triggers while producing inflammatory cytokines as well; expression of Wnt5a was recently reported in response to lipopolysaccharide (LPS) [15].

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