عنوان فایل ترجمه فارسی: بیماری آلزایمر؛ اختلال عملکرد سیناپسی.
عنوان نسخه انگلیسی: Alzheimers disease: synaptic dysfunction and Aβ
مرتبط با رشته : پزشکی
تعداد صفحات مقاله فارسی: ۱۶ صفحه
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قسمتی از متن انگلیسی:
The notion that dementia could result from
some sort of synaptic degeneration has been with us for over 100 years
and was eloquently expressed by Santiago Ramon y Cajal when he suggested
that “dementia could result when synapses between neurons are weakened
as a result of a more or less pathological condition, that is, when
processes atrophy and no longer form contacts, when cortical mnemonic or
association areas suffer partial disorganization” [16]. Quantification
using electron microscopy or immunohistochemical staining for synaptic
markers has documented significant decreases in synaptic density in the
association cortices and hippocampus of AD brain [13,14,17-21] and
biochemical and immunohistochemical analysis has revealed a similar loss
of both pre-synaptic and post-synaptic components [22]. Moreover, the
initial decrease in synapse number and density seems disproportionate to
the loss of neuronal cell bodies [13,18,23], suggesting that pruning of
synaptic endings may precede frank neuronal loss. Indeed, synaptic
degeneration appears to be an early event in pathogenesis with synapse
loss evident in patients with early AD and mild cognitive impairment
(MCI) [14,15,24]
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