دانلود ترجمه مقاله درباره هورمون رشد و استخوان Growth Hormone and Bone
عنوان فایل ترجمه فارسی: هورمون رشد و استخوان.
عنوان نسخه انگلیسی: Growth Hormone and Bone*
مرتبط با رشته : پزشکی
تعداد صفحات مقاله فارسی: ۳۰ صفحه
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قسمتی از متن انگلیسی:
Studies performed during the last 20 yr involving systemic administration of IGF-I to GH-deficient animals and man suggest that both IGF-I and GH have the capacity to stimulate longitudinal bone growth in vivo (45–۵۴). Elimination of IGF-I and the IGF-I receptor by homologous gene recombination have demonstrated that the IGF-I-signaling pathway is very important for tissue development and growth. Thus, mice with IGF-I deficiency show severe retardation of statural growth that first becomes apparent at day 12 in embryonic life, and subsequent postnatal growth is severely retarded (55–۵۸). IGF-I receptor “knock-out” mice are affected more profoundly and die of respiratory failure early postnatally due to poor development of respiratory muscles (57). Furthermore, a patient with a deletion of the IGF-I gene demonstrated intrauterine growth retardation and postnatal growth failure (59). These experimental studies and the clinical observation clearly demonstrate that a normal expression of IGF-I, as well as its receptor, plays a critical role for normal growth and tissue development. However, these experiments are unable to answer the question of whether locally produced (autocrine/paracrine acting) IGF-I is more important for normal tissue growth and development than circulating (endocrine acting) IGF-I.
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